Are Some Born that Way and Does It Matter?

We humans are diverse in our likes and dislikes, personalities, talents, and behavioral tendencies. Why? Are various tendencies, including sexual orientation, physically based (usually, but not always, meaning genetically determined)? Do they stem from our environment, the parenting we received, the friends we had, the stability or lack of it we experienced? Or are they really only a matter of choice? Do the answers to these questions make any difference as far as the Bible is concerned? That is, does a link to some physical factor, such as a particular genetic configuration, for what the Bible defines as sin absolve the person from responsibility?